The reality is that when comparing laser lipo vs. CoolSculpting, laser fat reduction is the clear winner for several reasons. Book a Free Consultation. Laser Lipo vs CoolSculpting: Key Differences. There are a few key differences between laser fat reduction and CoolSculpting that are essential to consider when looking for a fat loss treatment. CoolSculpting involves lower upfront costs, increasing its attraction to many men and women who are looking to moderately reduce fat in one or two targeted areas. If multiple CoolSculpting sessions are required, the costs may mount up and exceed the costs associated with liposuction. Speak to your plastic surgeon for advice if you are concerned.